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Effect of Cordyceps sinensis and taurine either alone or in combination on streptozotocin induced diabetes
Faculty
Pharmacy
Year:
2012
Type of Publication:
Article
Pages:
1159-1165
Authors:
Mahmoud, Mona F, El Ashry, Fatma El Zahraa Z, El Maraghy, Nabila N, Ahmed, Ahmed F
DOI:
10.1016/j.fct.2011.12.020
Journal:
FOOD AND CHEMICAL TOXICOLOGY PERGAMON-ELSEVIER SCIENCE LTD
Volume:
50
Research Area:
Food Science \& Technology; Toxicology
ISSN
ISI:000303284600098
Keywords :
Diabetes mellitus, STZ, Cordyceps sinensis, Taurine, Glibenclamide, Insulin resistance
Abstract:
The present study aimed to investigate the antidiabetic effects of Cordyceps sinensis, taurine and their combination in comparison with glibenclamide both in vivo and in vitro using streptozotocin rat model. The diabetic rats were orally given glibenclamide. C. sinensis, taurine or Cordyceps and taurine combination for 21 days. Their effects were studied both in vivo and in vitro. Oral administration of Cordyceps, taurine and their combination decreased serum glucose, fructosamine, total cholesterol, triglycerides levels, insulin resistance index and pancreatic malondialdehyde content. Cordyceps significantly increased serum insulin, HDL-cholesterol, total antioxidant capacity levels, beta cell function percent, and pancreatic reduced glutathione (GSH) content. However, taurine was unable to elevate pancreatic GSH level to a significant level. These natural products and their combinations were more effective than glibenclamide in reducing insulin resistance index and they had stronger antioxidant properties. Cordyceps and taurine significantly enhanced glucose uptake by diaphragms of normal and diabetic rats in absence and presence of insulin. In conclusion, Cordyceps and taurine either alone or in combination have less potent hypoglycemic effects than glibenclamide; however, they have more ability to reduce insulin resistance and stronger antioxidant properties. (C) 2011 Elsevier Ltd. All rights reserved.
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