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Chemical Constituents and Biological Activities of Senecio aegyptius var. discoideus Boiss.
Faculty
Pharmacy
Year:
2012
Type of Publication:
Article
Pages:
144-150
Authors:
Hassan, Wafaa, Al-Gendy, Amal, Al-youssef, Hanan, El-Shazely, Assem
Journal:
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES VERLAG Z NATURFORSCH
Volume:
67
Research Area:
Biochemistry \& Molecular Biology; Pharmacology \& Pharmacy
ISSN
ISI:000304740500006
Keywords :
Senecio aegyptius var. discoideus, Eremophilane Sesquiterpene, Flavonoids
Abstract:
A new eremophilane sesquiterpene, 1-beta-hydroxy-8-oxoeremophila-7,9-dien-12-oic acid (1), in addition to two known flavonol glycosides, rutin (2) and quercetin-3-O-glucoside-7-O-rutinoside (3), was isolated from the ethyl acetate fraction obtained from the aqueous alcoholic extract of the aerial parts of Senecio aegyptius var. discoideus Boiss. (family Asteraceae). The chemical structures of the isolated compounds were established by 1D and 2D NMR analysis (H-1, C-13, COSY, HMQC, HMBC), MS and UV data, and through comparison with the literature. The ethyl acetate fraction and the isolated rutin showed significant cytotoxic activity against colorectal carcinoma (HCT 116) and to less extent against brain (U 251) and breast carcinoma (MCF 7). The ethyl acetate fraction showed a significant level of activity against Klebsiella pneumoniae, while the total extract showed the best antifungal activity against Candida albicans and Saccharomyces cerevisiae. DPPH radical scavenging activity of the ethyl acetate fraction was significant (96.7\%) when compared to ascorbic acid. It also showed anti-inflammatory activity but no diuretic effect.
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