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Interleukin-4 polymorphisms and response to combination therapy in Egyptian chronic hepatitis C patients
Faculty
Medicine
Year:
2012
Type of Publication:
Article
Pages:
110-113
Authors:
Shalaby, Sally M, Radwan, Mohamed I, Nafee, Abeer M, Abdelazim, Shymaa
DOI:
10.1016/j.cellimm.2012.04.009
Journal:
CELLULAR IMMUNOLOGY ACADEMIC PRESS INC ELSEVIER SCIENCE
Volume:
276
Research Area:
Cell Biology; Immunology
ISSN
ISI:000307260800015
Keywords :
Hepatitis C virus, Interleukin-4 polymorphism, Interferon-alpha, Ribavirin
Abstract:
In hepatitis C infection, the production of inappropriate cytokines levels may contribute to viral persistence and may affect the response to antiviral therapy. We investigate the effect of IL4 C-590T and C-33T polymorphisms on the response to combination therapy with interferon and ribavirin in chronic HCV patients. These single nucleotide polymorphisms were determined by PCR-RFLP in 235 responder and 210 non-responder to combination therapy. The IL4-590 T/T and -33 T/T genotypes were associated with resistance to the therapy (p < 0.001, p = 0.001 respectively). Haplotypes T(-590) T( 33) and T(-590) C(-33) were associated with a higher risk in non-responder patients than the responders (p < 0.001 for each) while frequency of haplotype C(-590) C(-33) (with all wild alleles) was significantly higher in responders as compared to non-responders (p < 0.001). These results suggest that inheritance of the IL4 polymorphisms may be associated with resistance to combined antiviral therapy in Egyptian HCV patients. (C) 2012 Elsevier Inc. All rights reserved.
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