Synthesis, DNA binding studies of new pyrimidothiazepine and pyrimidobenzothiazepine derivatives

Several pyrimidothiazepine and pyrimidobenzothiazepine were synthesized starting from 6-chloro-1-methyluracil by the treatment with ethyl thioglycolate followed by the reaction with hydrazine hydrate which cyclized through refluxing with appropriate aromatic aldehydes or by the treatment with 2-aminothiophenol followed by refluxing with appropriate aromatic aldehydes respectively. The structure of newly synthesized compounds was confirmed by IR, 1H NMR, mass spectral data and elemental analysis. Further the novel derivatives were investigated for their binding and fragmentation of the nucleic acid DNA.