Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Subcutaneous Allergen-specific Immunotherapy Versus Topical Treatment in Vernal Keratoconjunctivitis
Faculty
Medicine
Year:
2012
Type of Publication:
Article
Pages:
525-528
Authors:
Nada, Waled M, Mahdy, Reda Abdel Rahman, Marei, Ayman A
DOI:
10.1097/ICO.0b013e3181eae270
Journal:
CORNEA LIPPINCOTT WILLIAMS \& WILKINS
Volume:
31
Research Area:
Ophthalmology
ISSN
ISI:000302788000010
Keywords :
subcutaneous allergen-specific immunotherapy (SCIT), topical, vernal keratoconjunctivitis
Abstract:
Purpose: The study evaluated the treatment of cases with vernal keratoconjunctivitis by subcutaneous allergen-specific immunotherapy (SCIT) versus topical treatment according to clinical improvement and total serum immunoglobulin (Ig) E. Design: Prospective randomized study. Methods: The study included 64 patients with bilateral vernal keratoconjunctivitis. Cases were divided into 2 groups: group 1, 32 patients who were subjected to topical treatment; and group 2, 32 patients who were subjected to intradermal skin reactions to different allergens. Prepared subcutaneous injections of different allergens were administered. Follow-up was performed to detect criteria of improvement according to clinical data and total serum IgE. Results: The study revealed that the treatment by SCIT was more effective in improving the clinical symptoms and reducing the serum IgE than topical treatment because there was a greater reduction in symptoms in group 1 of immunotherapy (72\%) than in group 2 of medical treatment (59\%) (P<0.05). Also, there was a significant reduction in total serum IgE (P<0.05) in group 1 (62\%) compared to group 2 (42\%). However, the intradermal test for each group of patients showed that 62\% of the patients were sensitive to pollens, 19\% to house dust, and 19\% to more than one allergen. Conclusions: Treatment of vernal keratoconjunctivitis by SCIT was more effective than topical treatment in improving the clinical symptoms and reducing the total serum IgE.
Online
PDF
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف