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Renin-angiotensin system genes polymorphism in Egyptians with premature coronary artery disease
Faculty
Medicine
Year:
2012
Type of Publication:
Article
Pages:
270-275
Authors:
Abd El-Aziz, Tarek A, Shalaby, Sally M, Hussein, Yousri M, Mohamed, Randa H
DOI:
10.1016/j.gene.2012.02.033
Journal:
GENE ELSEVIER SCIENCE BV
Volume:
498
Research Area:
Genetics \& Heredity
ISSN
ISI:000302888700018
Keywords :
RAS, Genetic polymorphism, Premature CAD
Abstract:
Genetics polymorphism of the renin-angiotensin system (RAS) affects the pathogenesis of atherosclerosis and associated with coronary artery disease (CAD). We aimed to investigate the association between the RAS genes and premature CAD (PCAD) in Egyptians. 116 patients with PCAD, 114 patients with late onset CAD and 119 controls were included in the study. Angiotensin converting enzyme (ACE), angiotensin II receptor type 1 (ATR1) and angiotensinogen (ACT) genes polymorphisms were analyzed by polymerase chain reaction (PCR). We found that ACE DD, ACT TT and ATR1 CC increased the risk of PCAD by 2.7, 2.8 and 2.86 respectively). Smoking, hypertension, diabetes,, total cholesterol, triglycerides and LDL cholesterol were independent risk factors for the development of PCAD. We conclude that the ACE DD, ACT IT and ATR1 CC genotypes may increase the susceptibility of an individual to have PCAD. The coexistence of CAD risk factors with these risky RAS genotypes may lead to the development of PCAD in Egyptian patients. (C) 2012 Elsevier B.V. All rights reserved.
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