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Vitamin D Supplementation in Infants With Chronic Congestive Heart Failure
Faculty
Not Specified
Year:
2012
Type of Publication:
Article
Pages:
713-719
Authors:
Shedeed, Soad A
DOI:
10.1007/s00246-012-0199-6
Journal:
PEDIATRIC CARDIOLOGY SPRINGER
Volume:
33
Research Area:
Cardiovascular System \& Cardiology; Pediatrics
ISSN
ISI:000304458900005
Keywords :
Vitamin D, Congestive heart failure, Renin-angiotensin system cytokines, Tumor necrosis factor-alpha
Abstract:
Increased circulating proinflammatory cytokines may contribute to the pathogenesis of congestive heart failure (CHF). In vitro studies have suggested that vitamin D suppresses proinflammatory cytokines and increases anti-inflammatory cytokines. The aim of this work was to evaluate the effect of vitamin D supplementation on renin-angiotensin system cytokines as well as different clinical, biochemical, and echocardiographic variables in infants with chronic CHF. This was a double-blind, placebo-controlled intervention study and included 80 infants with CHF. The intervention consisted of either giving Vitamin D-3 oral drops (group I) or placebo oral drops (group II). In both study groups, baseline 25-hydroxyvitamin D {[}25(OH)D] concentrations were below the lower end of the reference range. After 12 weeks of intervention, vitamin D supplementation for group I infants caused significant improvement of HF score, left-ventricular (LV) end-diastolic diameter, LV end-systolic diameter, LV ejection fraction\%, and myocardial performance index together with markedly increased serum 25(OH)D and interleukin (IL)-10 and decreased PTH, IL-6, and TNF-alpha compared with the placebo group; these differences were statistically significant (p < 0.001). Vitamin D supplementation has great benefits as an anti-inflammatory agent in infants with CHF. It helps acceleration of the clinical improvement and cytokine profile balance.
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