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Brain-derived neurotrophic factor Val66Met polymorphism and obsessive-compulsive symptoms in Egyptian schizophrenia patients
Faculty
Medicine
Year:
2012
Type of Publication:
Article
Pages:
762-766
Authors:
Fawzi, Mohab M, Karam, Rehab A, Hashim, Haytham M, Fawzy, Nagy
DOI:
10.1016/j.jpsychires.2012.03.007
Journal:
JOURNAL OF PSYCHIATRIC RESEARCH PERGAMON-ELSEVIER SCIENCE LTD
Volume:
46
Research Area:
Psychiatry
ISSN
ISI:000305494100011
Keywords :
Schizophrenia, Obsessive-compulsive symptoms, Brain-derived neurotrophic factor
Abstract:
Background: Brain-derived neurotrophic factor (BDNF) has been advanced as a candidate gene for schizophrenia. BDNF promote the function and growth of 5-HT neurons in the brain and modulate the synaptic plasticity of DRD3-secreting neurons in the striatum, suggesting involvement of BDNF in the mediation of obsessive-compulsive disorder. Objectives: To test the hypothesis that the BDNF Val66Met polymorphism influence obsessive-compulsive symptoms (OCS) in schizophrenia, we examined the association between the BDNF Val66Met genotypes and OCS in a group of patients with schizophrenia. Methods: 320 schizophrenia patients were assessed using the Yale Brown Obsessive-Compulsive Scale (YBOCS). BDNF Val66Met polymorphism was genotyped using PCR-RFLP method, and severity of OCS were compared between the genotype groups. Results: Out of the 320 schizophrenia patients, 120 patients (37.5\%) had significant OCS. There was a significant excess of valine allele in the schizophrenia with-OCS group compared to the without-OCS group. The mean YBOCS scores were significantly different among the three genotype groups. Val/Val homozygote patients had higher mean YBOCS scores compared to Val/Met genotype (p = 0.0001) as well as to the Met/Met homozygote group (p = 0.003). Conclusion: Our data suggested an association between BDNF Val66Met polymorphism and OCS in Egyptian schizophrenia patients. (C) 2012 Elsevier Ltd. All rights reserved.
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