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Bioactive Secondary Metabolites from Salix tetrasperma Roxb.
Faculty
Pharmacy
Year:
2012
Type of Publication:
Article
Pages:
353-359
Authors:
El-Shazly, Assem, El-Sayed, Afaf, Fikrey, Eman
Journal:
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES VERLAG Z NATURFORSCH
Volume:
67
Research Area:
Biochemistry \& Molecular Biology; Pharmacology \& Pharmacy
ISSN
ISI:000309699200001
Keywords :
Salix tetrasperma, Phenolic Glycosides, Biological Activity
Abstract:
Column chromatography of the light petroleum fraction from the methanolic extract of the stem bark of Salix tetrasperrna Roxb. (Salicaceae) resulted in the isolation of beta-sitosterol acetate, friedelin, 3 beta-friedelinol, beta-amyrin, beta-sitosterol, beta-sitosterol-O-glucoside in addition to palmitic acid. From the dichloromethane fraction of the leaves, catechol and tremulacin were isolated. Salicin and its derivatives tremuloidin and 2'-O-p-(E)-coumaroyl salicin were isolated from the ethyl acetate fraction of the leaves. The isolated compounds were identified by MS, and 1D NMR (H-1 and C-13) and 2D NMR (H-H COSY, HSQC, and HMBC) spectral analyses. The total methanolic extract exhibited significant anti-inflammatory activity (rat hind paw oedema). The extract with a content of 120 mg/kg body weight produced 52\% inhibition equivalent to the standard diclofenac sodium (54\% inhibition). The antioxidant (DPPH free radical scavenging) and analgesic activities, respectively, were also evaluated.
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