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The Role of Equine Herpesvirus Type 4 Glycoprotein K in Virus Replication
Faculty
Veterinary Medicine
Year:
2012
Type of Publication:
Article
Pages:
1258-1263
Authors:
Azab, Walid, El-Sheikh, Abuelyazeed
DOI:
10.3390/v4081258
Journal:
VIRUSES-BASEL MDPI AG
Volume:
4
Research Area:
Virology
ISSN
ISI:000308213000005
Keywords :
EHV-4, BAC, gK
Abstract:
Equine herpesvirus 4 (EHV-4) is an important equine pathogen that causes respiratory tract disease among horses worldwide. Glycoprotein K (gK) homologues have been identified in several alphaherpesviruses as a major player in virus entry, replication, and spread. In the present study, EHV-4 gK-deletion mutant has been generated by using bacterial artificial chromosome technology and Red mutagenesis to investigate the role of gK in EHV-4 replication. Our findings reported here show that gK is essential for virus replication in vitro and that the gK-negative strain was not able to be reconstituted in equine cells. It is noteworthy that these findings agree with the previously published study describing gK deletion in other alphaherpesviruses.
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