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Synergism of CYP2R1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Egyptian children
Faculty
Medicine
Year:
2012
Type of Publication:
Article
Pages:
42-45
Authors:
Mohamed, Randa H, Hussein, Atef G, Alghobashy, Ashgan A
DOI:
10.1016/j.cellimm.2012.08.006
Journal:
CELLULAR IMMUNOLOGY ACADEMIC PRESS INC ELSEVIER SCIENCE
Volume:
279
Research Area:
Cell Biology; Immunology
ISSN
ISI:000314259200006
Keywords :
CYP2R1, CYP27B1, Polymorphism, Type 1 diabetes
Abstract:
CYP2R1 (25 alpha-hydroxylase) catalyzes vitamin D-3 to 25-hydroxyvitamin D-3, while the CYP27B1 (1 alpha-hydroxylase) catalyzes the 25(OH)D-3 to 1, 25(OH)(2)D-3. 1, 25(OH)(2)D-3 prevents the development of autoimmune diabetes. We aimed to investigate CYP2R1 and CYP27B1 genes polymorphisms and susceptibility to type 1 diabetes in children. One hundred and twenty type 1 diabetic patients and One hundred and twenty controls were genotyped for CYP2R1 (rs10741657) and CYP27B1 (rs10877012) polymorphism. GG genotype of CYP2R1 increased risk to develop type 1 diabetes, and CC genotype of CYP27B1 increased risk to develop type 1 diabetes. Our finding suggested that GG genotype of CYP2R1 polymorphism and/or CC genotype of CYP27B1 polymorphism increased the risk of developing of type 1 diabetes in Egyptian children. In addition there was a synergism between GG genotype of CYP2R1 and CC genotype of CYP27B1 regarding the risk of development of type 1 diabetes. (c) 2012 Elsevier Inc. All rights reserved.
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