Palladium-Catalyzed Synthesis of Substituted Pyrido{[}2,3-d]pyridazines at Positions 5 and 8

Faculty Pharmacy Year: 2012
Type of Publication: Article Pages: 3216-3224
Authors:
Ibrahim, Mohamed A, El-Feky, Said A, Elagawany, Mohamed, Blaise, Emilie, Lozach, Olivier, Szalata, Claude, Schmitt, Martine, El-Etrawy, Abd-Allah S, Abdel-Samii, Zakraia K, Meijer, Laurent, Bourguignon, Jean-Jacques, Bihel, Frederic
DOI: 10.1055/s-0032-1317145
Journal: SYNTHESIS-STUTTGART GEORG THIEME VERLAG KG Volume: 44
Research Area: Chemistry ISSN ISI:000309813100015
Keywords : palladium, heterocycles, catalysis, cross-coupling    
Abstract:
Several synthetic strategies were developed for the preparation of highly substituted pyrido{[}2,3-d]pyridazines. We particularly focused on the impact of the pyridine nitrogen atom on pyridazine ring reactivity toward aromatic substitutions, alkylations, or pallado-catalyzed cross-coupling reactions.
    
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