HDL functionality in diabetes mellitus: potential importance of glycation

Faculty Pharmacy Year: 2012
Type of Publication: Article Pages: 561-578
Authors:
Younis, Nahla N, Durrington, Paul N
DOI: 10.2217/CLP.12.60
Journal: CLINICAL LIPIDOLOGY FUTURE MEDICINE LTD Volume: 7
Research Area: Biochemistry \& Molecular Biology ISSN ISI:000310416600013
Keywords : cholesteryl ester transfer protein, diabetes mellitus, dysfunctional HDL, glycation, HDL, lecithin:cholesterol acyl transferase, PON 1    
Abstract:
The incidence of atherosclerotic cardiovascular diseases correlates negatively with HDL. HDL has multiple potentially antiatherogenic properties that may be impaired in diabetes mellitus; in partciular, glycation of HDL could render it functionally deficient. This review explores the possible atheroprotective properties of HDL, the effect of diabetes mellitus and glycation on these properties and therapeutic interventions which could potentially reverse unfavorable deficiencies in HDL functionality.
    
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