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Diagnostic Performances of Hepatitis C Virus-NS4 Antigen in Patients with Different Liver Pathologies
Faculty
Science
Year:
2012
Type of Publication:
Article
Pages:
555-562
Authors:
Ghaly, Mohamed F, Attallah, Abdelfattah M, Omran, Mohamed M, Nasif, Wesam A, El-Shanshoury, Abd El-Raheem R, Abdalla, Mohga S, Sharada, Hayat M, Farid, Khaled, El-Shony, Wageh, Moussa, El-Sayed M, El-Domany, Ehab B, Nour, Eman, Eldosoky, Ibrahim
DOI:
10.1016/j.arcmed.2012.09.010
Journal:
ARCHIVES OF MEDICAL RESEARCH ELSEVIER SCIENCE INC
Volume:
43
Research Area:
Research \& Experimental Medicine
ISSN
ISI:000312119000008
Keywords :
HCV, Diagnosis, HCV-NS4 antigen, Liver pathologies
Abstract:
Background and Aims. Hepatitis C virus (HCV) has emerged as the major pathogen of liver disease worldwide. The aim of this study was to quantitate and evaluate the performance of HCV-NS4 antigen as an alternative approach for confirmation of viremia. Methods. Detection of HCV-NS4 was assessed in 883 patients with chronic hepatitis C. Areas under the ROC curves (AUC) were used to assess and compare diagnostic accuracy of ELISA for HCV-NS4 with quantitative HCV-RNA as a gold standard. Results. HCV-NS4 was identified at 27 kDa using Western blot. AUC for HCV-NS4 detection was 0.95 for all patients with different liver pathologies: 0.93 for liver fibrosis (LF), 0.95 for liver cirrhosis (LC) and 0.98 for hepatocellular carcinoma (HCC). The mean +/- SD (mu g/mL) of HCV-NS4 in LF was 94.2 +/- 55.6; in LC was 99.3 +/- 64.8 and in HCC was 124.9 +/- 70.3. Conclusions. HCV-NS4 antigen detection using ELISA is a reliable test in the confirmation of HCV infection. (C) 2012 IMSS. Published by Elsevier Inc.
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