Conductometric and Spectroscopic Determination of Mebeverine Hydrochloride and the Solubility Products of its Ion Recognition Species

Conductometric and spectroscopic determination of Mebeverine hydrochloride (MVH), a widely used antispasmodic, with two precipitating reagents; phosphomolybdic acid (PMA) and silver nitrate (AgNO3) has been investigated. Exploiting the conductometric procedure, the equilibrium constants and other functions associated with the process of precipitating MVH were determined. Moreover, two new maneuvers towards equivalence point detection were carried out. In this itinerary, data processing was performed applying numerical derivatization (first and second derivatives) and Boltzmann algorithm. The newly prescribed techniques were found to be more reasonable compared to the classical routine in terms of impartiality and rationality. The described procedures allowed the determination of MVH within the range of 2-15 mg using PMA and 1-20 mg using AgNO3 respectively. The molar ratio and as confirmed by the molar conductance - mole ratio plots, reveal that (1:1) (drug: reagent) ion associates are formed for both reagents with MVH. Furthermore, the precipitate obtained by ion pairing MVH with PMA has been spectroscopically characterized using IR and H-1-NMR. The method was further applied successively to pharmaceutical formulations containing MVH and the results obtained were favorably compared with those obtained using the official method.