Monitoring phospholipids for assessment of ion enhancement and ion suppression in ESI and APCI LC/MS/MS for chlorpheniramine in human plasma and the importance of multiple source matrix effect evaluations

Faculty Pharmacy Year: 2008
Type of Publication: ZU Hosted Pages: 333–343
Authors:
Omnia Ahmed Emam Ismaiel
Journal: Journal of Chromatography B USA Volume:
Keywords : Monitoring phospholipids , assessment , , enhancement , ion suppression , , , APCI    
Abstract:
Biological matrix effects are a source of significant errors in both electrospray (ESI) and atmospheric pressure chemical ionization (APCI) LC/MS. Glycerophosphocholines (GPChos) and 2-lysoglycerophosphocholines (2-lyso GPChos) are known
    
     
 
       

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