SYNTHESIS AND REACTION OF 6(9'-ANTHRACENYL)-3(2H)-PYRIDAZINONE DERIVATIVES AND STUDY OF THEIR MICROBIOLOGICAL ACTIVITY

Faculty Science Year: 1991
Type of Publication: Article Pages: 267-272
Authors:
ELFARARGY, AF, YASSIN, FA, ELMOBAYED, MM, ELKADY, MY, ELMAKSOUD, MRA
Journal: JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN CHEM SOC PAKISTAN Volume: 13
Research Area: Chemistry ISSN ISI:A1991JN41000013
Keywords : SYNTHESIS , REACTION , 6(9'-ANTHRACENYL)-3(2H)-PYRIDAZINONE DERIVATIVES , STUDY , THEIR    
Abstract:
The pyridazinone derivatives (a-e) were synthesized from the condensation of beta-(9-anthracenoyl) acrylic acid (1) with hydrazine derivatives. The behaviour of (2a) towards carbon electrophiles and carbon nucleophiles has been investigated. (2a) was reacted with alkylhalides under Grignard reaction conditions and ethyl bromoacetate under Reformatsky reaction conditions. Antibacterial activity of the prepared compounds were tested.
    
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