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DETERMINATION OF ETHAMBUTOL IN PHARMACEUTICAL PREPARATIONS BY ATOMIC-ABSORPTION SPECTROMETRY, SPECTROPHOTOMETRY AND POTENTIOMETRY
Faculty
Pharmacy
Year:
1992
Type of Publication:
Article
Pages:
193-199
Authors:
SHALABY, A, HASSAN, SSM
DOI:
10.1007/BF01242474
Journal:
MIKROCHIMICA ACTA SPRINGER-VERLAG WIEN
Volume:
109
Research Area:
Chemistry
ISSN
ISI:A1992KE27100001
Keywords :
PHARMACEUTICAL ANALYSIS, DETERMINATION OF ETHAMBUTOL, COPPER ELECTRODE, ATOMIC-ABSORPTION SPECTROMETRY, SPECTROPHOTOMETRY, COPPER-ETHAMBUTOL COMPLEX
Abstract:
Simple methods are described for the determination of ethambutol in pharmaceutical preparations. They are based on the reaction of the drug with copper phosphate suspension in a borate buffer of pH 9.2, whereby a blue 1 : 1 water-soluble copper-ethambutol complex is quantitatively formed. Four portions of the reaction solution are used for (i) measurement of copper by atomic-absorption spectrometry at 324.7 nm; (ii) potentiometric titration with EDTA with use of a solid-state copper ion-selective electrode; (iii) visual titration with EDTA (copper-PAN indicator); and (iv) spectrophotometric measurement of the copper-ethambutol complex at 640 nm. The results obtained are in good agreement and are better than those of the British Pharmacopoeia (BP) method.
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