Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Combination of non-invasive and semi-invasive tests for diagnosis of minimal to mild endometriosis
Faculty
Medicine
Year:
2013
Type of Publication:
Article
Pages:
793-797
Authors:
el Sharkwy, Ibrahim Abd Elgafor
DOI:
10.1007/s00404-013-2822-z
Journal:
ARCHIVES OF GYNECOLOGY AND OBSTETRICS SPRINGER HEIDELBERG
Volume:
288
Research Area:
Obstetrics \& Gynecology
ISSN
ISI:000324635900010
Keywords :
Non-invasive, Semi-invasive, Endometriosis, Serum IL-6, Nerve fibres
Abstract:
Non-surgical diagnostic approach for endometriosis would be of great gain to both physicians and patients. The aim of this study was to evaluate the diagnostic value of serum measurement of IL-6 combined with the presence of nerve fibres in the functional layer of endometrium for diagnosis of minimal-mild endometriosis. In this prospective study 114 women who underwent laparoscopy for infertility and/or pelvic pain were divided into two groups: control cases (40 cases) with no pathologic findings; and endometriosis patients (74 cases) {[}subdivided into stages 1-2 or minimal-mild (MM) and stages 3-4 or moderate-severe cases]. Blood was drawn one day before laparoscopy and stored for subsequent analysis of IL-6. Endometrial biopsy was obtained prior to laparoscopy and Immunohistochemistry was performed using the pan-neuronal marker protein gene product 9.5(PGP9.5). Then laparoscopic diagnosis of endometriosis confirmed by histopathology was done. Serum IL-6 with a threshold of 15.4 pg/ml was found to be able to diagnose MM endometriosis with 89.5 \% sensitivity and 82.5 \% specificity, but sensitivity and specificity of presence of nerve fibres in the functional layer of endometrium were 92 \% and 80 \% respectively. When two diagnostic modalities were combined the sensitivity and specificity were raised to 100 and 92.5 \% respectively. Combination of both serum IL-6 and presence of nerve fibres in the endometrium is more reliable method for diagnosis of MM endometriosis than in single test.
Online
PDF
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف