radiolabeling of cytotoxic drugs by technetium-99m and/or iodine-125 for therapeutic applications

In this thesis, the labeling of Thioguanine as a member of antimetabolites family was carried out by direct iodination of Thioguanine (100g) with radioiodine in a fast single step at 60ºC, to produce iodo-6-Thioguanine(125I-S6G). Chloramine-T (200g) wasAlso, in this thesis the labeling of Melphalan which is a member of alkylating agent’s family with radioactive iodine-125 was done. The optimum conditions of the labeling of Melphalan to give a radiochemical yield of 96.8 % were 200 g Melphalan, 150 l omice demonstrated the possibility of the use of this tracer as imaging or therapeutic agent for cancer .