| Abstract: |
The new complexes of second-generation fluoroquinolones antimicrobial drug groups, lomefloxacin hydrochloride (LFX) with Ti(IV), V(IV), Pd(II) and Ce(IV), and ofloxacin (HOfl.) of V(IV), Ti(IV Y(III), Zr(IV), Ce(IV) and U(VI) have been prepared. Also the complexes of the fourth generation fluoroquinolones moxifloxacin(MOX) with V(IV), Ti(IV), Y(III), Zr(IV), Pd(II), Ce(IV), U(VI) andTi(IV), Y(III), Zr(IV), Pd(II), Ce(IV) of veterinary fluoroquinolones enrofloxacin were isolated as solid complexes with a color characteristic of each metal ion. New complexes of Y(III), Zr(IV), and U(VI) with the anti-inflammatory drug ibuprofen (IBU) hmembered rings with the metal ions. The bond length and force constant F(U=O), in the uranyl complexes were calculated.The vibrational spectra of the final decomposition products indicate that the complexes finally decomposed to the corresponding metal oxwas studied against four species penicillium (P. rotatum), trichoderma T. sp.), aspergillus flarus (A. flarus) and aspergillus fumigates A. fumigates). The results showed significant increase in antibacterial activity of metal complexes as compared with uincrease in the activity is being considered due to increased bioavailability of the metal drug complexes.
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