various analytical techniques for determination of some antibiotics and its applications

The present work is develop new analytical spectrophotometric methods (Ion-Pair, Oxidation-Reduction and Charge Transfer techniques) for determination of some macrolide antibiotics, azithromycin (AZM), clarithromycin (CLM), roxithromycin (RXM), spiramycinThe present work comprises the following:The introduction which include two parts: the first part gives an idea about the importance of drug analysis and the studied reagents under consideration used for the different spectrophotometric methods, a discussion about the definitions, actions, chemiThe second part gives a literature survey of the previous studies for the analysis of the studied drugs including spectrophotometric, capillary electrophoresis, high-performance liquid chromatography, electro-analytical and other chromatographic methods. The experimental part which includes apparatus used for measurements and procedures for preparations of the drug solutions and reagents. It also contains the proposed spectrophotometric methos using diffrent techniques [ion-pair, charge transfer and oxidaThe results and discussion which include different experimental variables are investigated for the different spectrophotometric methods for the determination of the studied drugs:1- Ion-PairTechnique:2- Oxidation Reduction Technique :3- Charge Transfer Technique :The proposed methods was successfully applied to determine the studied drugs in the pure and in their dosage forms. The results obtained were compared statistically by Student’s t-test (for accuracy) and variance ratio F-test (for precision) with the offi