Synthesis and Antimalarial Bioassay of Quinine - Peptide Conjugates

Faculty	Pharmacy	Year:	2013
Type of Publication:	Article	Pages:	361-366
Authors:	Panda, Siva S, Ibrahim, Mohamed A, Kucukbay, Hasan, Meyers, Marvin J, Sverdrup, Francis M, El-Feky, Said A, Katritzky, Alan R	DOI:	10.1111/cbdd.12134
Journal:	CHEMICAL BIOLOGY \& DRUG DESIGN WILEY-BLACKWELL	Volume:	82
Research Area:	Biochemistry \& Molecular Biology; Pharmacology \& Pharmacy	ISSN	ISI:000324921500001
Keywords :	amino acid, chemical biology, drug design, peptide
Abstract:	Amino acid and peptide conjugates of quinine were synthesized using microwave irradiation in 52-95\% yields using benzotriazole methodology. The majority of these conjugates retain in vitro antimalarial activity with IC50 values below 100nm, similar to quinine.
	Online
PDF