Production and Characterization of Homocysteine γ -Lyase from Some Filamentous Fungi

Homocysteine -lyase (Hcy--lyase; Desulfhydrase) (E.C 4.4.1.2) is pyridoxal dependent enzyme, catalyze -elimination of homocysteine to hydrogen sulphide, ammonia and -ketobutyrate (Han et al., 1998). For the higher affinity of homocysteine -lyase for Hcy -lyase was received much attention during the last decade for its potency as anticancer, anti-cardiovascular agent, anti-diabetes and against other sulfur-metabolic disorders (Refsum, 1998 and Carmel and Jacobsen, 2001). Biochemically, the balance be