Synthesis and Biological Evaluation of some New Pyridazine derivatives

Pyridazine derivatives have recently received much attention from their reactions, and also, since many pyridazine derivatives were found to possess potential therapeutic effects, one can expect that replacement of a heterocyclic aromatic moiety by the pySulfonamides and sulfonylureas groups form the bioactive moiety of many compounds with therapeutically interest such as antibacterials, diuretics, antidiabetics and antibiotics (Lednicer et al., 1984). Also, mesoionic compounds have received much attentioAll these properties aroused my interest in synthesizing new heterocyclic compounds including the triazolo, thiazolo and thieno pyridazine moieties and studying their biological activities as antibacterial and antidiabetic agents