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Synthesis of Some New Benzisothiazolone and Benzenesulfonamide Derivatives of Biological Interest Starting from Saccharin Sodium
Faculty
Pharmacy
Year:
2013
Type of Publication:
Article
Pages:
733-742
Authors:
El-Sabbagh, Osama I
DOI:
10.1002/ardp.201300110
Journal:
ARCHIV DER PHARMAZIE WILEY-V C H VERLAG GMBH
Volume:
346
Research Area:
Pharmacology \& Pharmacy; Chemistry
ISSN
ISI:000325497500005
Keywords :
Antiviral activity, Benzenesulfonamide, Benzisothiazolone derivatives, Saccharin sodium, Synthesis
Abstract:
Two new series of benzenesulfonamide (4a-f, 5a-b, 6, 7) and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide (9a-c, 10, 12a-d) derivatives were prepared starting from saccharin sodium. The novel compounds were characterized using elemental analyses and different spectroscopic methods. Assessment of the antiviral activities of these novel compounds against a broad panel of viruses in different cell cultures revealed that only the thiazole derivatives belonging to the benzisothiazol-3(2H)-one-1,1-dioxide series are the active ones. All thiazole derivatives 12a-d showed activity against both varicella-zoster virus, especially TK- VZV strain 07-1, and the cytomegalovirus strains AD-169 and Davis in human embryonic lung (HEL) cell culture.
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