A Study on the Effect of Cerastes cerastes cerastes Venom on Pituitary Gonadal Axis in Experimental Animals

This study will be performed on mature male and female albino rats to determined the effect of C.c.c. venom on pituitary gonadal axis through measurement of the hormonal level change of FSH, LH, estrogen, progesterone, testosterone, cortisol and thyroxin Also some other parameters were measured to asses our conclusion such as serum and tissue level changes of protein, cholesterol, lipids and hepatic enzymes (ALT and AST).The experimental animals were be divided into 4 groups each one contain (5 males and 5 females). The 1st one used as control and the 2nd , 3rd and 4th group were injected intraperitoneally by (1/50, 1/20 and 1/10 LD50) of C.c.c. venom respectively, day afOn the other hand the results showed gradual increase in cortisol hormone in serum and in thyroid tissue also gradual rise appear in total lipids and in serum hepatic enzymes (ALT and AST) and serum total protein, while the tissue protein, cholesterol andThese results may be due to the toxic effects of C.c.c. venom on cells and cell organelles.The cytotoxins from venom caused mitochondrial deformation followed by cytoplasmic vaculisation and increase lysosomal vacules, thus affect on the cell activity and cell functions.