THE APPLICATION OF MICROWAYE IRRADIATION TECHNIQUE IN THE SYNTHESIS OF SOME PEPTIDE FRAHMENT ANALOGS OF INSULIN B-CHAIN

The biological activity of Insulin is known to be closely related to the C-terminal nonapeptide (B22-B30) fragment of its B-chain. This does not necessarily mean; however, that each of the amino acid residues of the nonapeptide fragment is essential for iA nonapeptide Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala-OH corresponding to (B22-B30) of Insulin B-chain was synthesized using different methods as liquid phase peptide synthesis (LPPS), modified solid phase peptide synthesis (slow batch method) and modified so