| Abstract: |
0 Pyrimidine derivatives and heteroannelated pyrimidines continue to attract great interest due to the wide variety of interesting biological activities observed for this compounds, such as anti-convulsant1, anti-inflamatory2, bactericidal3, fungicidal4, The enaminic carbon of enaminone(1) was added to the electrophilic carbon of 3-chloro- benzoyl isothiocyanate(2) to produce 4-mercapto-5-acetylpyrimidine derivative (3).Comp- ound (3)seemed to be of suitable located funactionality for further funclization1.S.Tripathi, S.Ahmed, Y.P.Borthwal, K.K.Tangri, K.Kishore and K.P.Bhorgava; Indian Y.Exptl.Bio.19,630(1981).2.C.Doria, C.Passaroti, G.Arcori and A.Buttinoni; Belg.Pat.893,835(1983); J.Chem. Abstr.99,70749(1983)3.G.P.Zhikhareva, L.L.Mastafanova, M.J.Evstratotova, I.M.Polukhina, T.V.Pushkina, G.N.Pershin and L.N.Yakhontovi; Khim. Farm.Zh.,16,183(1982);Chem. Abstr.;96, 199625(1982).4.G.P.Zhikharea, E.V.Pronina, E.A.Golovanova, G.N.Perghin, N.A.Novitshaya, T.N.Zykova, T.A.Guskova and L.N.Yakhnotov;Ibid,10,62,(1976); Chem. Abstr.,85,123848(1976)5.M.S.Manhas, S.G.Amin, S.D.Sharma, B.Dayal and K.A.Bose; J.Heterocycl. chem.;16,371(1979)0
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