Heterocyclization of some thiophenes with expected biological activity

In view of the pharmacological important of thiophene and their condensed systems. We synthesized some new thiophenes and their condensed derivatives hopping that they have significant biological activities.Nitrosation of thiophene derivative 1 with NaNO2 in HCl gave thienotrizine 3. Heterocyclization of thiophene 1 with carbon disulfide in sodium ethoxide gave thienopyrimidine 5. The acylation of thiophene 1 with acid chloride in acetic acid gave acylated d