Heterocyclization of some new condensed pyrimidines with expected biological activity

In view of the pharmacological importance of pyrimidines and their condensed systems, we synthesized some new pyrimidines and their condensed derivatives hopping that they have a significant biological activities.The synthesis of anilide 3 have been achieved by the reaction of 4-mercaptopyrimidine 1 with N(o-carboxyphenyl)chloroacetamide 2 in the presence of trimethylamine (TMA). Refluxing anilide 3 in aceticanhydride in the presence of fused sodiumacetate produceAlkylation of compound 1 using chloroaceticacid gives carboxymethylmercaptopyrimidine 10 which reacts with thionylchloride producing the corresponding acid chloride 11. Reaction of acid chloride 11 with ammoniumthiocynate gives thieno[2,3-d]pyrimidinoyl-i