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SYNTHESIS OF SOME NEW CONDENSED PYRIMIDINES - THIENOPTERIDINE AND PURINE DERIVATIVES
Faculty
Science
Year:
1993
Type of Publication:
Article
Pages:
109-111
Authors:
ELFARARGY, AF, ASSY, MG, HASSANIEN, MM
Journal:
PHARMAZIE GOVI-VERLAG GMBH
Volume:
48
Research Area:
Pharmacology \& Pharmacy; Chemistry
ISSN
ISI:A1993KW84300005
Keywords :
SYNTHESIS , SOME , CONDENSED PYRIMIDINES , THIENOPTERIDINE , PURINE
Abstract:
7-Hydroxypteridine (3) and its isomeric 6-hydroxypteridine (4) were prepared by condensation of 5,6-diaminouracil (1) with ethyl thienoylpyruvate (2) in pyridine and hydrochloric acid, respectively. Compounds 3 and 4 were converted into the corresponding thienopteridines 8 and 9 upon treatment with phosphorus pentasulphide. The synthesis of pteridines 12 and 13 was achieved from nitrosouracil (10). Also, the purine 15 and condensed purine 18 were prepared.
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