SPECTROPHOTOMETRIC DETERMINATION OF KETOPROFEN IN PHARMACEUTICAL PREPARATIONS BY MEANS OF CHARGE-TRANSFER COMPLEX-FORMATION

A spectrophotometric determination of ketoprofen based upon oxime formation followed by charge transfer complexation with o-chloranil has been developed. Different variables affecting the complexation process have been studied. Beer's law is obeyed in the concentration range 10-80 mug/ml. The method has been successfully applied to the determination of ketoprofen in pure form and in pharmaceutical dosage forms in the presence of its impurities.