STRUCTURAL ELUCIDATION OF GRISEOFULVIN-2,3-DICHLORO-5,6-DICYANOBENZOQUINONE COMPLEX

A sensitive spectrophotometric procedure for the estimation of griseofulvin (Antibiotic Antifungal) through electron transfer complexation reaction is proposed The pocedure was based on the interaction on the drug oxime with 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) in acetonitrile media). The optimal experimental conditions, molar ratio of reactants and the applicability of the suggested method to assay the drug in tablet forms were studied. The reaction product was isolated in a crystalline form and subjected to spectroscopic investigation by means of infrared (IR) and electron spin resonance (ESR) spectroscopy. The structure elucidation studies of the complex confirmed the radical ion formation.