FABRICATION OF AN ION-SELECTIVE ELECTRODE FOR DETERMINATION OF PROPYLHEXEDRINE

Electrodes of both conventional and micro-sizes were based on the use of propylhexedrine-reineckate as the ion-exchanger in a plastic membrane. The electrodes exhibited Nernstian response towards propylhexedrine (PX) over the concentration range 10(-6)-10(-2) M and had life spans of up to 2 days continuous work. The working pH range was 2.3-8. Investigation of diverse ions reveals good selectivity for propylhexedrine over several inorganic cations, amines, aminoacids, sugars and some pharmaceutical compounds. The electrode was applied for determination of the drug in urine with 99.1\% recovery and 0.15-0.31\% relative standard deviation.