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P53 AND C-ERBB-2 EXPRESSION IN SCHISTOSOMAL URINARY-BLADDER CARCINOMAS AND SCHISTOSOMAL CYSTITIS WITH PREMALIGNANT LESIONS
Faculty
Not Specified
Year:
1994
Type of Publication:
Article
Pages:
349-355
Authors:
Mangoud, A, KAMEL, D, SOINI, Y, NUORVA, K, KHALIFA, A, VAHAKANGAS, K, PAAKKO, P
Journal:
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY SPRINGER VERLAG
Volume:
424
Research Area:
Pathology
ISSN
ISI:A1994NZ50000003
Keywords :
P53, C-ERBB-2, BLADDER CARCINOMA, SCHISTOSOMIASIS
Abstract:
Immunoreactivity for p53 and c-erbB-2 proteins was studied in 31 schistosomal urinary bladder carcinomas and 21 cases of schistosomal cystitis with hyperplastic, metaplastic and/or dysplastic (premaligant) lesions. The results were compared with 30 carcinomas and 21 premalignant lesions of the urinary bladder without schistosomiasis. Abnormal nuclear p53 protein accumulation was found in 17/31 schistosomal and in 15/30 non-schistosomal carcinomas and in 8/21 schistosomal cystitis with premalignant lesions of which five showed hyperplasia. No case of non-schistosomal hyperplasia or squamous metaplasia examined showed p53-positivity. In non-schistosomal carcinomas p53 positivity was significantly associated with tumour grade (grade I-II vs grade III tumours: P = 0.021) and greater age (P = 0.004) while in schistosomal carcinomas no such associations were found. Cytoplasmic membrane-bound positivity for c-erbB-2 oncoprotein was found in comparable percentages in schistosomal and non-schistosomal bladder carcinomas (10\%), and in both groups was co-expressed with p53. p53 gene alteration is an important event in the development of both schistosomal and non-schistosomal bladder carcinoma.
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